(OSHA Work Practice Guidelines), Am J. Health- Syst Pharm, 1996; 53:1669-1685. We comply with the HONcode standard for trustworthy health information -. (For more detail, see … Single doses as high as 3 g/m2 have been administered by rapid intravenous infusion without apparent toxicity. Therapeutic abortions were done in five cases. Doses of 4.5 g/m2 by intravenous infusion over 1 hour every 12 hours for 12 doses have caused an unacceptable increase in irreversible CNS toxicity and death. You should not be treated with cytarabine if you are allergic to it. Patients treated with high-dose Cytarabine should be observed for neuropathy since dose schedule alterations may be needed to avoid irreversible neurologic disorders. Following 5-day constant infusions or acute injections of 50 mg/m2 to 600 mg/m2, white cell depression follows a biphasic course. Protect from light. Patients receiving this drug must be under close medical supervision and, during induction therapy, should have leucocyte and platelet counts performed daily. Sterile, Nonpyrogenic, Preservative-free. There is no antidote for overdosage of Cytarabine. It has also been found useful in the treatment of acute lymphocytic leukemia and the blast phase of chronic myelocytic leukemia. Cytarabine in combination with other approved anticancer drugs is indicated for remission induction in acute non-lymphocytic leukemia of adults and children. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Viral, bacterial, fungal, parasitic, or saprophytic infections, in any location in the body may be associated with the use of Cytarabine alone or in combination with other immunosuppressive agents following immunosuppressant doses that affect cellular or humoral immunity. During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. Not all possible drug interactions are listed here. Cytarabine is chemically 1-β-D-Arabinofuranosylcytosine. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. American Society of Hospital Pharmacists Technical Assistance Bulletin on Handling Cytotoxic and Hazardous Drugs. Cytarabine is usually given together with steroid medicine to help lessen these side effects. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), … Only physicians experienced in cancer chemotherapy should use Cytarabine. Like other cytotoxic drugs, Cytarabine may induce hyperuricemia secondary to rapid lysis of neoplastic cells. Med J Australia, 1983; 1:426-428. The structural formula is: Cytarabine is an odorless, white to off-white crystalline powder which is freely soluble in water and slightly soluble in alcohol and in chloroform. Cytarabine, ARA-C is a FDA pregnancy risk category D drug. Medscape - Acute myeloid leukemia dosing for Vyxeos (cytarabine/ daunorubicin liposomal), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. To report SUSPECTED ADVERSE REACTIONS, contact Meitheal Pharmaceuticals Inc. at 1-844-824-8426 or FDA at 1-800-FDA-1088 or. A review of the literature has shown 32 reported cases where Cytarabine was given during pregnancy, either alone or in combination with other cytotoxic agents: Eighteen normal infants were delivered. Cytarabine is often given by continuous intravenous infusion, which follows a biphasic elimination – initial fast clearance rate followed by a slower rate of the analog. Pharm, 1990; 47:1033-1049. Uses. Although the mechanism of action is not completely understood, it appears that Cytarabine acts through the inhibition of DNA polymerase. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Following rapid intravenous injection of Cytarabine labeled with tritium, the disappearance from plasma is biphasic. The frequency of administration varied from once a day for 4 days to once every 4 days. This cardiac toxicity may be schedule dependent. Cytarabine has been used effectively alone or with other chemotherapeutic agents in the treatment and maintenance therapy of meningeal leukemia and other meningeal neoplasms (e.g., lymphoma). Because of the potential for abnormalities with cytotoxic therapy, particularly during the first trimester, a patient who is or who may become pregnant while on Cytarabine should be apprised of the potential risk to the fetus and the advisability of pregnancy continuation. Cytarabine is rapidly metabolized and is not effective orally; less than 20 percent of the orally administered dose is absorbed from the gastrointestinal tract. Decreased steady-state ... L01BC01 - cytarabine ; Belongs to the class of antimetabolites, pyrimidine analogues. Procedures for proper handling and disposal of anti-cancer drugs should be considered. cytarabine is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. Cytarabine is usually given together with a … Main purpose: Voreloxin is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, inducing site-selective DNA damage. Cytarabine is contraindicated in those patients who are hypersensitive to the drug. Cytarabine is also used alone or with other chemotherapy drugs to treat meningeal leukemia (cancer in the membrane that covers and protects the spinal cord and brain). Copyright 1996-2018 Cerner Multum, Inc. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Cytarabine can cause serious side effects on your brain or central nervous system that may not be reversible. It usually occurs 6 to 12 hours following drug administration. Nandy P(1), Lien EJ, Avramis VI. Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. 83-2621. Dosage ... cytarabine ; Belongs to the class of antimetabolites, pyrimidine analogues. This medication is classified as an "antimetabolite." Cytarabine is a pyrimidine analog and is incorporated into DNA; however, the primary action is inhibition of DNA polymerase resulting in decreased DNA synthesis and repair. However, in one patient in whom cerebrospinal fluid levels are examined after 2 hours of constant intravenous infusion, levels approached 40 percent of the steady state plasma level. Am J. Hosp. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Cytarabine | C9H13N3O5 | CID 6253 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, … Cytarabine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Each mL contains 20 mg Cytarabine, USP (20 mg per mL) in a single dose vial (100 mg per 5 mL). Cytarabine is employed either as a single agent or in combination with others, specially the anthracyclines, and is the prime example of an antitumor drug specifically acting in the S-phase of the cell cycle because its incorporation into DNA after being activated to the corresponding triphosphate leads to inhibition of strand elongation (Fig. One case of anaphylaxis that resulted in acute cardiopulmonary arrest and required resuscitation has been reported. This problem tends to be less severe when the drug is infused.